{"id":13620,"date":"2023-07-27T10:19:38","date_gmt":"2023-07-27T10:19:38","guid":{"rendered":"https:\/\/uleidecanepa.com\/?p=13620"},"modified":"2023-08-01T12:07:08","modified_gmt":"2023-08-01T12:07:08","slug":"uleiul-cbd-si-schizofrenia-drumul-catre-o-noua-terapie","status":"publish","type":"post","link":"https:\/\/uleidecanepa.com\/2023\/07\/27\/uleiul-cbd-si-schizofrenia-drumul-catre-o-noua-terapie\/","title":{"rendered":"Uleiul CBD \u0219i Schizofrenia: Drumul C\u0103tre O Nou\u0103 Terapie?"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"512\" src=\"https:\/\/uleidecanepa.com\/wp-content\/uploads\/2023\/07\/ulei-CBD-si-schizofrenia-1024x512.jpg\" alt=\"\" class=\"wp-image-13621\" srcset=\"https:\/\/uleidecanepa.com\/wp-content\/uploads\/2023\/07\/ulei-CBD-si-schizofrenia-980x490.jpg 980w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2023\/07\/ulei-CBD-si-schizofrenia-480x240.jpg 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1024px, 100vw\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Ce este Schizofrenia?<\/h2>\n\n\n\n<p>Schizofrenia este o tulburare mental\u0103 complex\u0103 \u0219i debilitant\u0103 care afecteaz\u0103 aproximativ 1% din popula\u021bia mondial\u0103. Aceast\u0103 afec\u021biune are impact asupra modului \u00een care o persoan\u0103 g\u00e2nde\u0219te, simte \u0219i se comport\u0103, interfer\u00e2nd cu capacitatea sa de a func\u021biona \u00een via\u021ba de zi cu zi. De\u0219i cauza exact\u0103 a schizofreniei nu este pe deplin cunoscut\u0103, se crede c\u0103 aceasta rezult\u0103 dintr-o combina\u021bie de factori genetici, neurochimici \u0219i de mediu.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Simptomele Schizofreniei: O C\u0103l\u0103torie \u00een Lumea Complex\u0103 a Min\u021bii<\/strong><\/h2>\n\n\n\n<p>Schizofrenia este caracterizat\u0103 prin manifestarea unui spectru variat de simptome, care se \u00eempart \u00een dou\u0103 categorii principale: simptomele pozitive \u0219i simptomele negative.<\/p>\n\n\n\n<p>Simptomele pozitive sunt rezultatul unei hiperactivit\u0103\u021bi a dopaminei \u00een creier \u0219i includ:<\/p>\n\n\n\n<ul>\n<li><strong>Halucina\u021bii<\/strong>: Un joc misterios de forme \u0219i culori, halucina\u021biile auditore pot fi experimentate sub forma unor voci amenin\u021b\u0103toare sau ciudate. \u00cen rare cazuri, halucina\u021biile pot lua forme vizuale, tactile, olfactive sau gustative.<\/li>\n\n\n\n<li><strong>Delir<\/strong>: Ideile delirante contureaz\u0103 imagini colorate \u0219i contradictorii, f\u0103r\u0103 leg\u0103tur\u0103 cu realitatea. Chiar \u0219i \u00een fa\u021ba unor argumente solide, pacien\u021bii r\u0103m\u00e2n fideli acestor convingeri ireale.<\/li>\n\n\n\n<li><strong>Paranoia<\/strong>: Un v\u00e2rtej de culori \u0219i forme, paranoia aduce umbre de ne\u00eencredere \u0219i suspiciune, duc\u00e2nd la sentimente de urm\u0103rire sau de citire a g\u00e2ndurilor.<\/li>\n\n\n\n<li><strong>G\u00e2ndire Dezorganizat\u0103 \u0219i Comportament Haotic<\/strong>: O palet\u0103 de cuvinte \u0219i ac\u021biuni, f\u0103r\u0103 o logic\u0103 aparent\u0103, definesc simptomele unei min\u021bi dezorganizate \u0219i a unui comportament haotic.<\/li>\n<\/ul>\n\n\n\n<p>Pe de alt\u0103 parte, simptomele negative apar din cauza unui deficit al dopaminei \u00een lobul frontal al creierului \u0219i includ:<\/p>\n\n\n\n<ul>\n<li><strong>Tendin\u021ba de izolare<\/strong>: Pacientul se retrage social \u0219i prezint\u0103 dificult\u0103\u021bi \u00een interac\u021biunea cu cei din jur.<\/li>\n\n\n\n<li><strong>Alogie:<\/strong> Limbajul devine s\u0103rac, iar bolnavul nu preia ini\u021biativa \u00een discu\u021bii, ci r\u0103spunde \u00een propozi\u021bii simple \u0219i lipsite de con\u021binut.<\/li>\n\n\n\n<li><strong>Avolitie<\/strong>: Motiva\u021bia este extrem de sc\u0103zut\u0103, iar pacientul nu mai dore\u0219te s\u0103 se implice \u00een activit\u0103\u021bi.<\/li>\n\n\n\n<li><strong>Aplatizarea emo\u021biilor<\/strong>: Reac\u021biile emo\u021bionale sunt reduse sau chiar absente.<\/li>\n\n\n\n<li><strong>Sentimente de inutilitate:<\/strong> Pacientul poate sim\u021bi c\u0103 nu are nicio valoare \u0219i c\u0103 nu poate realiza nimic \u00een via\u021b\u0103.<\/li>\n\n\n\n<li><strong>Dificult\u0103\u021bi \u00een desf\u0103\u0219urarea activit\u0103\u021bilor zilnice:<\/strong> Pacientul \u00eent\u00e2mpin\u0103 dificult\u0103\u021bi \u00een \u00eendeplinirea sarcinilor obi\u0219nuite de zi cu zi.<\/li>\n<\/ul>\n\n\n\n<p>\u00cen\u021belegerea acestor simptome complexe ale schizofreniei este vital\u0103 \u00een abordarea adecvat\u0103 a acestei afec\u021biuni mentale. Tratamentul, sprijinul \u0219i educarea comunit\u0103\u021bii sunt instrumente esen\u021biale pentru a oferi ajutor pentru pacien\u021bii afecta\u021bi de schizofrenie. Prin recunoa\u0219terea diversit\u0103\u021bii \u0219i a valorii fiec\u0103rei persoane, putem crea un tablou mai empatic \u0219i mai incluziv, \u00een care toate culorile min\u021bii s\u0103 str\u0103luceasc\u0103 \u00een armonie.<\/p>\n\n\n\n<p><a href=\"https:\/\/uleidecanepa.com\/ghidul\/boli\/schizofrenie\/\" target=\"_blank\" rel=\"noreferrer noopener\">Schizofrenia <\/a>poate afecta persoanele de orice v\u00e2rst\u0103, dar debutul este adesea \u00een adolescen\u021b\u0103. Pacien\u021bii cu schizofrenie pot avea dificult\u0103\u021bi majore \u00een men\u021binerea rela\u021biilor personale \u0219i profesionale, ceea ce poate conduce la izolare social\u0103 \u0219i la un impact semnificativ asupra calit\u0103\u021bii vie\u021bii.<\/p>\n\n\n\n<p>Tratamentul schizofreniei implic\u0103, \u00een general, o combina\u021bie de terapie psihosocial\u0103 \u0219i medicamente antipsihotice. Cu toate acestea, tratamentul este adesea dificil \u0219i uneori ineficient, ceea ce face ca c\u0103utarea de noi abord\u0103ri terapeutice s\u0103 fie esen\u021bial\u0103.<\/p>\n\n\n\n<p>\u00cen ultimii ani, cercet\u0103rile au \u00eendreptat aten\u021bia c\u0103tre un compus din planta de cannabis &#8211; canabidiolul (CBD), care pare s\u0103 ofere o nou\u0103 speran\u021b\u0103 \u00een tratamentul schizofreniei. Urmeaz\u0103 s\u0103 explor\u0103m mai detaliat cum <a href=\"https:\/\/uleidecanepa.com\/#ulei-cbd\" target=\"_blank\" rel=\"noreferrer noopener\">CBD-ul <\/a>poate afecta simptomele \u0219i func\u021biile cognitive asociate cu schizofrenia, deschiz\u00e2nd astfel noi perspective \u00een abordarea acestei tulbur\u0103ri complexe a s\u0103n\u0103t\u0103\u021bii mentale.<\/p>\n\n\n<div data-block-name=\"woocommerce\/handpicked-products\" data-columns=\"4\" data-edit-mode=\"false\" data-content-visibility=\"{&quot;title&quot;:true,&quot;price&quot;:true,&quot;rating&quot;:false,&quot;button&quot;:true}\" data-orderby=\"popularity\" data-products=\"[13001,3178,170,449]\" class=\"wc-block-grid wp-block-handpicked-products wc-block-handpicked-products has-4-columns has-multiple-rows\"><ul class=\"wc-block-grid__products\"><li class=\"wc-block-grid__product\">\n\t\t\t\t<a href=\"https:\/\/uleidecanepa.com\/produse\/medihemp-10-cbd-cbda-ulei-10ml\/\" class=\"wc-block-grid__product-link\">\n\t\t\t\t\t<div class=\"wc-block-grid__product-onsale\">\n\t\t\t<span aria-hidden=\"true\">V\u00e2nzare<\/span>\n\t\t\t<span class=\"screen-reader-text\">Produs cu reducere<\/span>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"wc-block-grid__product-image\"><img loading=\"lazy\" width=\"400\" height=\"400\" src=\"https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-10_10ml_de_kombi_1500-400x400.jpg\" class=\"attachment-woocommerce_thumbnail size-woocommerce_thumbnail\" alt=\"Ulei CBD + CBDa Complete 10%, 10ML (1000MG), BIO, MEDIHEMP\" decoding=\"async\" srcset=\"https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-10_10ml_de_kombi_1500-400x400.jpg 400w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-10_10ml_de_kombi_1500-150x150.jpg 150w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-10_10ml_de_kombi_1500-300x300.jpg 300w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-10_10ml_de_kombi_1500-768x768.jpg 768w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-10_10ml_de_kombi_1500-1024x1024.jpg 1024w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-10_10ml_de_kombi_1500-610x610.jpg 610w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-10_10ml_de_kombi_1500-1080x1080.jpg 1080w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-10_10ml_de_kombi_1500-510x510.jpg 510w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-10_10ml_de_kombi_1500-100x100.jpg 100w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-10_10ml_de_kombi_1500.jpg 1500w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/div>\n\t\t\t\t\t<div class=\"wc-block-grid__product-title\">Ulei CBD + CBDa Complete 10%, 10ML (1000MG), BIO, MEDIHEMP<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<div class=\"wc-block-grid__product-price price\"><del aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\">319&nbsp;<span class=\"woocommerce-Price-currencySymbol\">lei<\/span><\/span><\/del> <ins><span class=\"woocommerce-Price-amount amount\">278&nbsp;<span class=\"woocommerce-Price-currencySymbol\">lei<\/span><\/span><\/ins><\/div>\n\t\t\t\t\n\t\t\t\t<div class=\"wp-block-button wc-block-grid__product-add-to-cart\"><a href=\"?add-to-cart=170\" aria-label=\"Adaug\u0103 &bdquo;Ulei CBD + CBDa Complete 10%, 10ML (1000MG), BIO, MEDIHEMP&rdquo; 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\u00een co\u0219ul t\u0103u\" data-quantity=\"1\" data-product_id=\"3178\" data-product_sku=\"100001201\" rel=\"nofollow\" class=\"wp-block-button__link  add_to_cart_button ajax_add_to_cart\">Adaug\u0103 \u00een co\u0219<\/a><\/div>\n\t\t\t<\/li><li class=\"wc-block-grid__product\">\n\t\t\t\t<a href=\"https:\/\/uleidecanepa.com\/produse\/2-x-medihemp-complete-5-30ml-pachet-2-buc-x-30ml\/\" class=\"wc-block-grid__product-link\">\n\t\t\t\t\t<div class=\"wc-block-grid__product-onsale\">\n\t\t\t<span aria-hidden=\"true\">V\u00e2nzare<\/span>\n\t\t\t<span class=\"screen-reader-text\">Produs cu reducere<\/span>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"wc-block-grid__product-image\"><img loading=\"lazy\" width=\"400\" height=\"400\" src=\"https:\/\/uleidecanepa.com\/wp-content\/uploads\/2023\/02\/5x2-400x400.jpg\" class=\"attachment-woocommerce_thumbnail size-woocommerce_thumbnail\" alt=\"2 x MediHemp Complete 5% 30ml - pachet (2 buc x 30ml)\" decoding=\"async\" srcset=\"https:\/\/uleidecanepa.com\/wp-content\/uploads\/2023\/02\/5x2-400x400.jpg 400w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2023\/02\/5x2-150x150.jpg 150w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2023\/02\/5x2-300x300.jpg 300w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2023\/02\/5x2-768x768.jpg 768w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2023\/02\/5x2-1024x1024.jpg 1024w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2023\/02\/5x2-610x610.jpg 610w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2023\/02\/5x2-1080x1080.jpg 1080w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2023\/02\/5x2-510x510.jpg 510w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2023\/02\/5x2-100x100.jpg 100w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2023\/02\/5x2.jpg 1200w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/div>\n\t\t\t\t\t<div class=\"wc-block-grid__product-title\">2 x MediHemp Complete 5% 30ml &#8211; pachet (2 buc x 30ml)<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<div class=\"wc-block-grid__product-price price\"><del aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\">718&nbsp;<span class=\"woocommerce-Price-currencySymbol\">lei<\/span><\/span><\/del> <ins><span class=\"woocommerce-Price-amount amount\">599&nbsp;<span class=\"woocommerce-Price-currencySymbol\">lei<\/span><\/span><\/ins><\/div>\n\t\t\t\t\n\t\t\t\t<div class=\"wp-block-button wc-block-grid__product-add-to-cart\"><a href=\"?add-to-cart=13001\" aria-label=\"Adaug\u0103 &bdquo;2 x MediHemp Complete 5% 30ml - pachet (2 buc x 30ml)&rdquo; \u00een co\u0219ul t\u0103u\" data-quantity=\"1\" data-product_id=\"13001\" data-product_sku=\"530x2csomag\" rel=\"nofollow\" class=\"wp-block-button__link  add_to_cart_button ajax_add_to_cart\">Adaug\u0103 \u00een co\u0219<\/a><\/div>\n\t\t\t<\/li><\/ul><\/div>\n\n\n<h2 class=\"wp-block-heading\"><strong>Canabidiolul (CBD-ul) \u0219i schizofrenia<\/strong><\/h2>\n\n\n\n<p>\u00cen ultimii ani, cercet\u0103torii au \u00eendreptat aten\u021bia spre un compus din planta de cannabis, numit CBD. <a href=\"https:\/\/uleidecanepa.com\/ulei-cbd-canabis\/\" data-type=\"URL\" data-id=\"https:\/\/uleidecanepa.com\/ulei-cbd-canabis\/\">CBD-ul este diferit<\/a> de delta-9-tetrahidrocannabinol (THC), alt compus din cannabis, care este responsabil pentru efectele psihotrope. \u00cen contrast cu acest compus, CBD nu are propriet\u0103\u021bi psihoactive \u0219i nu creeaz\u0103 dependen\u021b\u0103. De fapt, studiile au ar\u0103tat c\u0103 CBD-ul poate avea efecte antipsihotice \u0219i poate modula sistemul de dopamin\u0103 mezolimbic \u00eentr-un mod promi\u021b\u0103tor pentru tratamentul schizofreniei.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>CBD \u0219i Schizofrenie &#8211; O Combinatie Promi\u021b\u0103toare<\/strong><\/h2>\n\n\n\n<p>Cum poate <a rel=\"noreferrer noopener\" href=\"https:\/\/uleidecanepa.com\/ulei-cbd-canabis\/\" target=\"_blank\">CBD <\/a>s\u0103 influen\u021beze schizofrenia? Studiile clinice \u0219i preclinice au investigat aceast\u0103 \u00eentrebare \u0219i au descoperit c\u0103 CBD-ul poate modula activitatea dopaminergic\u0103, asociat\u0103 cu simptomele psihotice. \u00cen plus, CBD-ul interac\u021bioneaz\u0103 cu receptorul de serotonin\u0103 5-HT1A, av\u00e2nd efecte benefice asupra func\u021biilor cognitive asociate schizofreniei. Aceste cercet\u0103ri sunt promi\u021b\u0103toare \u0219i sugereaz\u0103 c\u0103 CBD-ul poate normaliza deficitele afective \u0219i cognitive specifice bolii.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-1 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/uleidecanepa.com\/#ulei-cbd\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Arat\u0103 produsele<\/strong><\/a><\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Studii<em> in vivo<\/em> \u0219i <em>in vitro<\/em><\/strong><\/h3>\n\n\n\n<p>Dovezile privind poten\u021bialul terapeutic al CBD\u2013ul au fost ob\u021binute dintr-o varietate de studii. \u00cen studiile <em>in vitro<\/em>, CBD-ul a fost testat \u00een culturile de celule pentru a evalua efectele sale asupra receptorilor \u0219i func\u021biilor neuronale. Studiile pe animale au fost efectuate pe modele de \u0219oareci \u0219i \u0219obolani, care au furnizat date importante despre modul \u00een care CBD-ul afecteaz\u0103 sistemul nervos central. \u00cen cele din urm\u0103, studiile clinice umane au implicat pacien\u021bi cu schizofrenie sau cu risc crescut de psihoz\u0103 \u0219i au demonstrat efecte promi\u021b\u0103toare \u00een ameliorarea simptomelor \u0219i func\u021biilor cognitive.<\/p>\n\n\n\n<p>\u00cen studiile in vitro, cercet\u0103torii au investigat cum ac\u021bioneaz\u0103 CBD-ul la nivel celular \u0219i molecular. Au fost efectuate experimente pe culturi de celule neuronale pentru a evalua interac\u021biunea CBD-ului cu receptorii \u0219i c\u0103ile neuronale implicate \u00een schizofrenie. Aceste studii au demonstrat c\u0103 CBD-ul poate modula activitatea receptorilor de serotonin\u0103 \u0219i dopamin\u0103, influen\u021b\u00e2nd astfel procesele neuronale implicate \u00een apari\u021bia simptomelor psihozei. De asemenea, s-a observat c\u0103 CBD-ul poate reduce inflama\u021bia \u0219i proteja celulele nervoase \u00eempotriva stresului oxidativ, suger\u00e2nd poten\u021bialul s\u0103u neuroprotectiv.<\/p>\n\n\n\n<p>Experimentele pe animale au oferit o \u00een\u021belegere mai detaliat\u0103 a modului \u00een care CBD-ul afecteaz\u0103 sistemul nervos central. Studiile pe modele de \u0219oareci \u0219i \u0219obolani au ar\u0103tat c\u0103 <a href=\"https:\/\/uleidecanepa.com\/#ulei-cbd\" target=\"_blank\" rel=\"noreferrer noopener\">CBD-ul poate reduce<\/a> comportamentele legate de anxietate \u0219i agresiune, oferind oamenilor de \u0219tiin\u021b\u0103 indicii c\u0103 ar putea avea efecte calmante \u0219i antipsihotice. De asemenea, CBD-ul a demonstrat poten\u021bial \u00een ameliorarea disfunc\u021biilor cognitive \u0219i a deficitelor de memorie la animalele cu afec\u021biuni similare schizofreniei. Aceste rezultate promi\u021b\u0103toare au servit drept baza pentru a explora mai departe efectele CBD-ului \u00een studiile clinice umane.<\/p>\n\n\n\n<p>Cercet\u0103rile clinice au fost esen\u021biale pentru a evalua efectele CBD-ului asupra pacien\u021bilor cu schizofrenie sau cu risc crescut de psihoz\u0103. Studiile au implicat pacien\u021bi care au primit tratament cu CBD pentru a evalua modul \u00een care acest compus afecteaz\u0103 simptomele \u0219i func\u021biile cognitive. Rezultatele au fost promi\u021b\u0103toare, ar\u0103t\u00e2nd c\u0103 CBD-ul poate reduce simptomele psihotice pozitive, precum halucina\u021biile \u0219i delirurile. De asemenea, s-a observat o ameliorare a deficitelor cognitive asociate cu schizofrenia. Importan\u021ba acestei descoperiri const\u0103 \u00een faptul c\u0103 tratamentele antipsihotice actuale au o eficacitate limitat\u0103 \u00een ameliorarea acestor simptome \u0219i func\u021bii cognitive.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-2 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/uleidecanepa.com\/#ulei-cbd\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Arat\u0103 produsele<\/strong><\/a><\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Concluzii \u0219i Perspective<\/strong><\/h2>\n\n\n\n<p>Studiile clinice \u0219i preclinice au furnizat dovezi c\u0103 CBD-ul poate avea poten\u021bial terapeutic pentru <a href=\"https:\/\/uleidecanepa.com\/ghidul\/boli\/schizofrenie\/\" target=\"_blank\" rel=\"noreferrer noopener\">tratamentul schizofreniei<\/a>. CBD-ul se diferen\u021biaz\u0103 de THC prin faptul c\u0103 nu are efecte psihoactive \u0219i poate oferi beneficii antipsihotice f\u0103r\u0103 a produce efecte secundare asociate cu THC. Studiile <em>in vitro<\/em> au ar\u0103tat c\u0103 CBD ac\u021bioneaz\u0103 asupra receptorilor de serotonin\u0103 \u0219i dopamin\u0103, influen\u021b\u00e2nd astfel func\u021biile neuronale implicate \u00een psihoz\u0103. Rezultatele studiilor pe animale au confirmat efectele calmante \u0219i antipsihotice ale CBD-ului, iar studiile clinice umane au adus \u00een plus dovezi c\u0103 CBD poate ameliora simptomele \u0219i func\u021biile cognitive asociate cu schizofrenia.<\/p>\n\n\n\n<p>CBD-ul reprezint\u0103 o nou\u0103 speran\u021b\u0103 pentru pacien\u021bii cu schizofrenie \u0219i pentru cei afecta\u021bi de alte tulbur\u0103ri neuropsihiatrice. Cu un poten\u021bial terapeutic promi\u021b\u0103tor \u0219i propriet\u0103\u021bi neuroprotectoare \u0219i antiinflamatorii, CBD-ul ar putea deveni un tratament inovator \u0219i bine tolerat pentru schizofrenie. Cu toate acestea, pentru a confirma \u0219i valida efectele sale benefice, este necesar\u0103 continuarea cercet\u0103rii \u0219i realizarea de studii ample \u0219i riguroase pe pacien\u021bi. Astfel, \u00een viitorul apropiat, CBD-ul ar putea aduce o schimbare semnificativ\u0103 \u00een abordarea \u0219i tratarea schizofreniei, oferind speran\u021b\u0103 \u0219i \u00eembun\u0103t\u0103\u021bind calitatea vie\u021bii pacien\u021bilor afecta\u021bi de aceast\u0103 afec\u021biune complex\u0103.<\/p>\n\n\n<div data-block-name=\"woocommerce\/handpicked-products\" data-columns=\"4\" data-edit-mode=\"false\" data-content-visibility=\"{&quot;title&quot;:true,&quot;price&quot;:true,&quot;rating&quot;:false,&quot;button&quot;:true}\" data-orderby=\"popularity\" data-products=\"[13295,11774,386,449]\" class=\"wc-block-grid wp-block-handpicked-products wc-block-handpicked-products has-4-columns has-multiple-rows\"><ul class=\"wc-block-grid__products\"><li class=\"wc-block-grid__product\">\n\t\t\t\t<a href=\"https:\/\/uleidecanepa.com\/produse\/medihemp-5-cbd-cbda-ulei-30ml\/\" class=\"wc-block-grid__product-link\">\n\t\t\t\t\t<div class=\"wc-block-grid__product-onsale\">\n\t\t\t<span aria-hidden=\"true\">V\u00e2nzare<\/span>\n\t\t\t<span class=\"screen-reader-text\">Produs cu reducere<\/span>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"wc-block-grid__product-image\"><img loading=\"lazy\" width=\"400\" height=\"400\" src=\"https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-5_30ml_de_kombi_1500-400x400.jpg\" class=\"attachment-woocommerce_thumbnail size-woocommerce_thumbnail\" alt=\"Ulei CBD + CBDa Complete 5%, 30ML (1500MG), BIO, MEDIHEMP\" decoding=\"async\" srcset=\"https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-5_30ml_de_kombi_1500-400x400.jpg 400w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-5_30ml_de_kombi_1500-150x150.jpg 150w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-5_30ml_de_kombi_1500-300x300.jpg 300w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-5_30ml_de_kombi_1500-768x768.jpg 768w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-5_30ml_de_kombi_1500-1024x1024.jpg 1024w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-5_30ml_de_kombi_1500-610x610.jpg 610w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-5_30ml_de_kombi_1500-1080x1080.jpg 1080w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-5_30ml_de_kombi_1500-510x510.jpg 510w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-5_30ml_de_kombi_1500-100x100.jpg 100w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-5_30ml_de_kombi_1500.jpg 1500w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/div>\n\t\t\t\t\t<div class=\"wc-block-grid__product-title\">Ulei CBD + CBDa Complete 5%, 30ML (1500MG), BIO, MEDIHEMP<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<div class=\"wc-block-grid__product-price price\"><del aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\">359&nbsp;<span class=\"woocommerce-Price-currencySymbol\">lei<\/span><\/span><\/del> <ins><span class=\"woocommerce-Price-amount amount\">308&nbsp;<span class=\"woocommerce-Price-currencySymbol\">lei<\/span><\/span><\/ins><\/div>\n\t\t\t\t\n\t\t\t\t<div class=\"wp-block-button wc-block-grid__product-add-to-cart\"><a href=\"?add-to-cart=449\" aria-label=\"Adaug\u0103 &bdquo;Ulei CBD + CBDa Complete 5%, 30ML (1500MG), BIO, MEDIHEMP&rdquo; \u00een co\u0219ul t\u0103u\" data-quantity=\"1\" data-product_id=\"449\" data-product_sku=\"100000301\" rel=\"nofollow\" class=\"wp-block-button__link  add_to_cart_button ajax_add_to_cart\">Adaug\u0103 \u00een co\u0219<\/a><\/div>\n\t\t\t<\/li><li class=\"wc-block-grid__product\">\n\t\t\t\t<a href=\"https:\/\/uleidecanepa.com\/produse\/medihemp-10-cbd-cbda-ulei-30ml\/\" class=\"wc-block-grid__product-link\">\n\t\t\t\t\t<div class=\"wc-block-grid__product-onsale\">\n\t\t\t<span aria-hidden=\"true\">V\u00e2nzare<\/span>\n\t\t\t<span class=\"screen-reader-text\">Produs cu reducere<\/span>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"wc-block-grid__product-image\"><img loading=\"lazy\" width=\"400\" height=\"400\" src=\"https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-10_30ml_de_kombi_1500-400x400.jpg\" class=\"attachment-woocommerce_thumbnail size-woocommerce_thumbnail\" alt=\"Ulei CBD + CBDa Complete 10%, 30ML (3000MG), MEDIHEMP\" decoding=\"async\" srcset=\"https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-10_30ml_de_kombi_1500-400x400.jpg 400w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-10_30ml_de_kombi_1500-150x150.jpg 150w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-10_30ml_de_kombi_1500-300x300.jpg 300w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-10_30ml_de_kombi_1500-768x768.jpg 768w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-10_30ml_de_kombi_1500-1024x1024.jpg 1024w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-10_30ml_de_kombi_1500-610x610.jpg 610w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-10_30ml_de_kombi_1500-1080x1080.jpg 1080w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-10_30ml_de_kombi_1500-510x510.jpg 510w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-10_30ml_de_kombi_1500-100x100.jpg 100w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/04\/complete-10_30ml_de_kombi_1500.jpg 1500w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/div>\n\t\t\t\t\t<div class=\"wc-block-grid__product-title\">Ulei CBD + CBDa Complete 10%, 30ML (3000MG), MEDIHEMP<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<div class=\"wc-block-grid__product-price price\"><del aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\">740&nbsp;<span class=\"woocommerce-Price-currencySymbol\">lei<\/span><\/span><\/del> <ins><span class=\"woocommerce-Price-amount amount\">649&nbsp;<span class=\"woocommerce-Price-currencySymbol\">lei<\/span><\/span><\/ins><\/div>\n\t\t\t\t\n\t\t\t\t<div class=\"wp-block-button wc-block-grid__product-add-to-cart\"><a href=\"?add-to-cart=386\" aria-label=\"Adaug\u0103 &bdquo;Ulei CBD + CBDa Complete 10%, 30ML (3000MG), MEDIHEMP&rdquo; \u00een co\u0219ul t\u0103u\" data-quantity=\"1\" data-product_id=\"386\" data-product_sku=\"100000601\" rel=\"nofollow\" class=\"wp-block-button__link  add_to_cart_button ajax_add_to_cart\">Adaug\u0103 \u00een co\u0219<\/a><\/div>\n\t\t\t<\/li><li class=\"wc-block-grid__product\">\n\t\t\t\t<a href=\"https:\/\/uleidecanepa.com\/produse\/medihemp-5-cbd-cbda-capsule-30-buc\/\" class=\"wc-block-grid__product-link\">\n\t\t\t\t\t<div class=\"wc-block-grid__product-onsale\">\n\t\t\t<span aria-hidden=\"true\">V\u00e2nzare<\/span>\n\t\t\t<span class=\"screen-reader-text\">Produs cu reducere<\/span>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"wc-block-grid__product-image\"><img loading=\"lazy\" width=\"400\" height=\"400\" src=\"https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/08\/5-kapsz-400x400.jpg\" class=\"attachment-woocommerce_thumbnail size-woocommerce_thumbnail\" alt=\"MEDIHEMP 5% CBD+CBDA CAPSULE 60BUC. (25MG)\" decoding=\"async\" srcset=\"https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/08\/5-kapsz-400x400.jpg 400w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/08\/5-kapsz-150x150.jpg 150w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/08\/5-kapsz-300x300.jpg 300w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/08\/5-kapsz-768x768.jpg 768w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/08\/5-kapsz-1024x1024.jpg 1024w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/08\/5-kapsz-610x610.jpg 610w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/08\/5-kapsz-1080x1080.jpg 1080w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/08\/5-kapsz-510x510.jpg 510w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/08\/5-kapsz-100x100.jpg 100w, https:\/\/uleidecanepa.com\/wp-content\/uploads\/2017\/08\/5-kapsz.jpg 1500w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/div>\n\t\t\t\t\t<div class=\"wc-block-grid__product-title\">MEDIHEMP 5% CBD+CBDA CAPSULE 60BUC. (25MG)<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<div class=\"wc-block-grid__product-price price\"><del aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\">239&nbsp;<span class=\"woocommerce-Price-currencySymbol\">lei<\/span><\/span><\/del> <ins><span class=\"woocommerce-Price-amount amount\">198&nbsp;<span class=\"woocommerce-Price-currencySymbol\">lei<\/span><\/span><\/ins><\/div>\n\t\t\t\t\n\t\t\t\t<div class=\"wp-block-button wc-block-grid__product-add-to-cart\"><a href=\"https:\/\/uleidecanepa.com\/produse\/medihemp-5-cbd-cbda-capsule-30-buc\/\" aria-label=\"Cite\u0219te mai multe despre &bdquo;MEDIHEMP 5% CBD+CBDA CAPSULE 60BUC. (25MG)&rdquo;\" data-quantity=\"1\" data-product_id=\"11774\" data-product_sku=\"100000401off\" rel=\"nofollow\" class=\"wp-block-button__link  add_to_cart_button\">Cite\u0219te mai mult<\/a><\/div>\n\t\t\t<\/li><li class=\"wc-block-grid__product\">\n\t\t\t\t<a href=\"https:\/\/uleidecanepa.com\/produse\/medihemp-bio-balance-spray-de-gura-cu-cbd-5\/\" class=\"wc-block-grid__product-link\">\n\t\t\t\t\t<div class=\"wc-block-grid__product-onsale\">\n\t\t\t<span aria-hidden=\"true\">V\u00e2nzare<\/span>\n\t\t\t<span class=\"screen-reader-text\">Produs cu reducere<\/span>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"wc-block-grid__product-image\"><img loading=\"lazy\" width=\"400\" height=\"400\" src=\"https:\/\/uleidecanepa.com\/wp-content\/uploads\/2023\/03\/ezgif.com-gif-maker-4-400x400.jpg\" class=\"attachment-woocommerce_thumbnail size-woocommerce_thumbnail\" alt=\"Medihemp Bio Balance \u2013 spray de gur\u0103 cu CBD (5%)\" decoding=\"async\" \/><\/div>\n\t\t\t\t\t<div class=\"wc-block-grid__product-title\">Medihemp Bio Balance \u2013 spray de gur\u0103 cu CBD (5%)<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t<div class=\"wc-block-grid__product-price price\"><del aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\">169&nbsp;<span class=\"woocommerce-Price-currencySymbol\">lei<\/span><\/span><\/del> <ins><span class=\"woocommerce-Price-amount amount\">144&nbsp;<span class=\"woocommerce-Price-currencySymbol\">lei<\/span><\/span><\/ins><\/div>\n\t\t\t\t\n\t\t\t\t<div class=\"wp-block-button wc-block-grid__product-add-to-cart\"><a href=\"?add-to-cart=13295\" aria-label=\"Adaug\u0103 &bdquo;Medihemp Bio Balance \u2013 spray de gur\u0103 cu CBD (5%)&rdquo; \u00een co\u0219ul t\u0103u\" data-quantity=\"1\" data-product_id=\"13295\" data-product_sku=\"spray-balance\" rel=\"nofollow\" class=\"wp-block-button__link  add_to_cart_button ajax_add_to_cart\">Adaug\u0103 \u00een co\u0219<\/a><\/div>\n\t\t\t<\/li><\/ul><\/div>\n\n\n<p><strong>Bibliografie:<\/strong><\/p>\n\n\n\n<ol type=\"1\" start=\"1\">\n<li>McGuire, P., Robson, P., Cuba\u0142a, W. J., Vasile, D., Morrison, P., Barron, R., Taylor, A., &amp; Wright, S. (2018). Cannabidiol (CBD) as an adjunctive therapy in schizophrenia: a multicenter randomized controlled trial. American Journal of Psychiatry, 175(3), 225\u2013231.<a href=\"https:\/\/doi.org\/10.1176\/appi.ajp.2017.17030325\"> https:\/\/doi.org\/10.1176\/appi.ajp.2017.17030325<\/a><\/li>\n\n\n\n<li>Boggs, D. L., Surti, T., Gupta, A., et al. (2018). The effects of cannabidiol (CBD) on cognition and symptoms in outpatients with chronic schizophrenia: a randomized placebo-controlled trial. Psychopharmacology, 235, 1923\u20131932.<a href=\"https:\/\/doi.org\/10.1007\/s00213-018-4885-9\"> https:\/\/doi.org\/10.1007\/s00213-018-4885-9<\/a><\/li>\n\n\n\n<li>Ahmed, S., Roth, R. M., Stanciu, C. N., &amp; Brunette, M. F. (2021). The impact of THC and CBD in schizophrenia: a systematic review. Frontiers in Psychiatry, 12, 694394. doi:10.3389\/fpsyt.2021.694394<\/li>\n\n\n\n<li>Zuardi, A. W., Hallak, J. E. C., Dursun, S. M., et al. (2006). Cannabidiol monotherapy for treatment-resistant schizophrenia. Journal of Psychopharmacology, 20(5), 683-686. doi:10.1177\/0269881106060967<\/li>\n\n\n\n<li>Morgan, C., &amp; Curran, H. (2008). Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis. The British Journal of Psychiatry, 192(4), 306-307. doi:10.1192\/bjp.bp.107.046649<\/li>\n\n\n\n<li>Schoevers, J., Leweke, J. E., Leweke, F. M. (2020). Cannabidiol as a treatment option for schizophrenia: recent evidence and current studies. Current Opinion in Psychiatry, 33(3), 185-191.<a href=\"https:\/\/doi.org\/10.1097\/YCO.0000000000000596\"> https:\/\/doi.org\/10.1097\/YCO.0000000000000596<\/a><\/li>\n\n\n\n<li>Manseau, M. W., &amp; Goff, D. C. (2015). Cannabinoids and schizophrenia: risks and therapeutic potential. Neurotherapeutics, 12, 816\u2013824.<a href=\"https:\/\/doi.org\/10.1007\/s13311-015-0382-6\"> https:\/\/doi.org\/10.1007\/s13311-015-0382-6<\/a><\/li>\n\n\n\n<li>Renard, J., Norris, C., Rushlow, W., &amp; Laviolette, S. R. (2017). Neuronal and molecular effects of cannabidiol on the mesolimbic dopamine system: implications for novel schizophrenia treatments. Neuroscience &amp; Biobehavioral Reviews, 75, 157\u2013165.<a href=\"https:\/\/doi.org\/10.1016\/j.neubiorev.2017.02.006\"> https:\/\/doi.org\/10.1016\/j.neubiorev.2017.02.006<\/a><\/li>\n<\/ol>\n    <div class=\"related-post slider\">\r\n                <div class=\"headline\">Post\u0103ri asem\u0103natoare<\/div>\r\n        <div class=\"post-list owl-carousel\">\r\n\r\n                        <div class=\"item\">\r\n                        <div class=\"thumb post_thumb\">\r\n        <a  title=\"Ulei CBD &#8211; Mod de administrare\" href=\"https:\/\/uleidecanepa.com\/2019\/04\/11\/dozaj-cbd-cat-cbd-ar-trebui-sa-iau\/\">\r\n\r\n            <img loading=\"lazy\" width=\"400\" height=\"250\" src=\"https:\/\/uleidecanepa.com\/wp-content\/uploads\/2019\/04\/Benefits-of-CBD-Oil-Learn-Sativa-University-1024x535-400x250.jpg\" class=\"attachment-et-pb-post-main-image size-et-pb-post-main-image wp-post-image\" alt=\"\" decoding=\"async\" \/>\r\n\r\n        <\/a>\r\n    <\/div>\r\n\r\n    <a class=\"title post_title\"  title=\"Ulei CBD &#8211; Mod de administrare\" href=\"https:\/\/uleidecanepa.com\/2019\/04\/11\/dozaj-cbd-cat-cbd-ar-trebui-sa-iau\/\">\r\n                Ulei CBD &#8211; Mod de administrare    <\/a>\r\n\r\n                <\/div>\r\n                            <div class=\"item\">\r\n                        <div class=\"thumb post_thumb\">\r\n        <a  title=\"Sindrom premenstrual, Endometrioz\u0103, Migren\u0103, Sindromul ovarelor polichistice &#8211; Cum poate ajuta uleiul CBD?\" href=\"https:\/\/uleidecanepa.com\/2019\/10\/28\/pms-endometrioza-migrena-pcos-cum-ajuta-uleiul-cbd-pentru-femeii\/\">\r\n\r\n            <img loading=\"lazy\" width=\"400\" height=\"250\" src=\"https:\/\/uleidecanepa.com\/wp-content\/uploads\/2019\/10\/this-cannabis-retreat-for-women-sounds-like-the-best-thing-ever-hero-750x500-400x250.jpg\" class=\"attachment-et-pb-post-main-image size-et-pb-post-main-image wp-post-image\" alt=\"\" decoding=\"async\" \/>\r\n\r\n        <\/a>\r\n    <\/div>\r\n\r\n    <a class=\"title post_title\"  title=\"Sindrom premenstrual, Endometrioz\u0103, Migren\u0103, Sindromul ovarelor polichistice &#8211; Cum poate ajuta uleiul CBD?\" href=\"https:\/\/uleidecanepa.com\/2019\/10\/28\/pms-endometrioza-migrena-pcos-cum-ajuta-uleiul-cbd-pentru-femeii\/\">\r\n                Sindrom premenstrual, Endometrioz\u0103, Migren\u0103, Sindromul ovarelor polichistice &#8211; Cum poate ajuta uleiul CBD? 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Schizofrenia este o tulburare mental\u0103 complex\u0103 \u0219i debilitant\u0103 care afecteaz\u0103 aproximativ 1% din popula\u021bia mondial\u0103. Aceast\u0103 afec\u021biune are impact asupra modului \u00een care o persoan\u0103 g\u00e2nde\u0219te, simte \u0219i se comport\u0103, interfer\u00e2nd cu capacitatea sa de a func\u021biona \u00een via\u021ba de zi cu zi. De\u0219i cauza exact\u0103 a schizofreniei nu este pe deplin [&hellip;]<\/p>\n","protected":false},"author":131,"featured_media":13621,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"off","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[1],"tags":[38,80],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.4 (Yoast SEO v21.4) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Uleiul CBD \u0219i Schizofrenia: Drumul C\u0103tre O Nou\u0103 Terapie? - ULEI de CANEPA<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/uleidecanepa.com\/2023\/07\/27\/uleiul-cbd-si-schizofrenia-drumul-catre-o-noua-terapie\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Uleiul CBD \u0219i Schizofrenia: Drumul C\u0103tre O Nou\u0103 Terapie?\" \/>\n<meta property=\"og:description\" content=\"Ce este Schizofrenia? Schizofrenia este o tulburare mental\u0103 complex\u0103 \u0219i debilitant\u0103 care afecteaz\u0103 aproximativ 1% din popula\u021bia mondial\u0103. Aceast\u0103 afec\u021biune are impact asupra modului \u00een care o persoan\u0103 g\u00e2nde\u0219te, simte \u0219i se comport\u0103, interfer\u00e2nd cu capacitatea sa de a func\u021biona \u00een via\u021ba de zi cu zi. 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